Paul Pogba could be sidelined for up to a month after damaging his thigh in Manchester United's draw with Everton.
The French international limped off during the first half of Saturday's disappointing 3-3 draw with the Toffees at Old Trafford.
Scans have revealed muscle damage and the news is a huge blow to United's title chances.
Pogba has been in impressive form in recent weeks to help United climb to second in the Premier League table.
But he will now miss tonight's FA Cup clash with West Ham along with crucial league fixtures against Newcastle, West Brom and Chelsea.
The midfielder, who will also miss two Europa League showdowns with Real Sociedad, is now facing a race against time to be fit for United's crunch trip to league leaders Manchester City on March 6.
Boss Ole Gunnar Solskjaer said: "It's an injury that will take a few weeks to heal.
"He's just started his recovery, working with the medical staff and we'll get him back as soon and as safely as we can.
"Of course, Paul has been very important for us and we're not going to take any risks. So it is a few weeks definitely.
"You never want to be injured and, especially, now Paul was really finding his form and enjoying his football. For us, we just have to take as many points and wins as possible, when you lose players.
"We've been very healthy and strong for a long period so we can't moan too much."
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