Manchester United welcome Newcastle United to Old Trafford on Sunday knowing a win will move them one step closer to securing Champions League football next season.
But Ole Gunnar Solskjaer may have to secure a victory without a number of his key men at his disposal.
Paul Pogba, Edinson Cavani, Scott McTominay and Donny van de Beek, who have all played a part in recent games, will all miss out.
And Phil Jones continues to recover from a knee problem which has hampered his career in recent seasons.
Speaking about injuries this week, Solskjaer said: "Paul's recovering. He's starting the treatment.
"It'll still be a few weeks, he won't be playing in February that's for sure.
"It's still a few weeks until we see Paul, definitely.
"Donny and Edinson are injured unfortunately, muscle injuries, so they won’t travel.
"Apart from that, we have a couple of doubtful ones, if they'll be fit enough – Anthony [Martial] and Scott [McTominay]."
And at the start of the month, Solskjaer also addressed Jones' long-running problem.
"He has been recovering from a knee injury, an op he had," he said.
"Hopefully, he'll get his fitness back sooner rather than later and be available."
Solskjaer may again look to give some youth prospects a chance this weekend.
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Amad Diallo and Shola Shoretire were on the bench against Real Sociedad in midweek, with the former coming off the bench for his senior debut.
"Well we give them a chance to come to United and have a successful career," Solskjaer also said this week.
"That is something we take serious and are good at. We like to give players a chance. Our fans, our history has always been about skilfull attacking players."
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