NFL Week 6 betting guide: Odds, key matchups, stats & trends, injury report for every game

Get a leg up on all 14 matchups slated for Week 6 NFL betting as we dive into the stats, injury updates and early betting odds in this game-by-game betting guide. We’ve got you covered with great tips, insight and betting angles for profitable NFL picks. Let’s get started.

New York Giants vs. New England Patriots

The New England Patriots are flush off 33-7 win over the hapless Washington Redskins, a straightforward win that saw them cover a big spread (-16.5 closing) easily. The upshot of which is a five-game winning streak that sends Patriots into week 6 as double-digit faves (-17.5 opening) over a side that doesn’t rank high in general estimation but does boast an intriguing rookie quarterback, who many rate favorably.

The NY Giants two-game winning streak came to an abrupt halt against the Minnesota Vikings defense. The 28-10 loss left much to be desired, not to mention left their backers on the hook as the Giants (+6 closing) failed to make a game of it.

Naturally following week 5, early betting shows a distinct lean towards the Patriots with 62% of early bets going towards the big home faves. News that Saquon Barkley may make a return in this game, combined with the Giants tradition of punching above their weight class in this matchup has some backing the Giants for Week 6 NFL picks though.

To be fair, it is a lot of points to leave on the table. However, Daniel Jones has never seen an elite defense and that alone makes it impossible to imagine how he could keep this game close. Keep in mind, it’s a short week as well.

NFL Betting Trends

— Patriots are 7-2-0 ATS in their last 9 games
— Patriots are 5-0 SU in their last 5 games at home
— Giants are 2-4-0 ATS in their last 6 games
— Giants are 8-1-0 ATS in their last 9 games on the road

Key Injuries

NYG – TE Evan Engram (Knee), T Nate Solder (Ankle), LB Josiah Tauaefa (Knee) and LB Lorenzo Carter (Neck) are all listed as questionable for Thursday Night Football (TNF). WR Sterling Shephard (Concussion) is out indefinitely. DL RJ McIntosh (Concussion) is doubtful for TNF.

NE – WR Julian Edelman (Chest) and WR Josh Gordon (Knee), both listed as probably for TNF. WR Phillip Dorset II (Hamstring), RB Rex Burkhead (Foot), S Patrick Chung (Heel) and DB Nate Ebner (Groin) are listed as questionable for TNF.

Carolina Panthers vs. Tampa Bay Buccaneers

Betting on this game depends heavily on whether the Panthers start Kyle Allen again or they revert back to Cam Newton, who might be ready to resume his position as the starter. Under Allen, the Panthers are a winning team. Riding a three-game winning streak that includes a 3-0-0 ATS mark. With Newton the Panthers are 0-2 SU and ATS, which includes a 20-14 loss to the Bucs in Week 2 at home as the -6.5-point closing chalk.

Vegas rolled out a pick’em NFL line at early doors, essentially letting the market temper this game. Early betting trends reveal the Panthers are attracting more attention than the Bucs, forcing the NFL line to move from a PK in their favor. As it is, they are laying -2 on the NFL odds board.

This is understandable given the week 5 results. The Bucs crashed back to earth behind a 31-24 loss to the Saints. That they didn’t stack the wins following the upset in week 4 over the Rams has taken the shine off of the Bucs.

All in all, this is a tough matchup to bet on. We don’t know for certain which quarterback Ron Riviera will field, but we do know Jameis Winston blows hot and cold from week to week. That alone makes the Bucs a risky bet against a Panthers defense that could give him fits.

NFL Betting Trends

— Panthers are 4-2-0 ATS in their last 6 games
— Panthers are 4-2 SU in their last 6 games
— The total has gone OVER in 4 of Carolina’s last 6 games
— Buccaneers are 4-9 SU in last 13 games vs Panthers

Key Injuries

CAR – LB Christian Miller (Ankle) and DB Natrell Jamerson (Ankle) are both listed as day-to-day.

TB – G Alex Cappa (Arm) is out indefinitely. T Demar Dotson (Hamstring) is listed as day-to-day.

Seattle Seahawks vs. Cleveland Browns

Before Monday Night Football, Vegas tipped the Cleveland Browns as the home favorites for this week 6 NFL matchup. Following the 31-3 loss to the Niners by the Browns, the market corrected itself forthwith. Now, the NFL line sits with the Browns tipped as the notable +1 or +1.5 home underdogs.

For those NFL bettors that jumped on the Seahawks as the +2.5 road underdogs, all that can be said is, bravo. That was a steal bet that most likely will pay dividends for Week 6 NFL picks. Having said that, there is still value to be had with the Seahawks as the road faves.

The Seahawks are in fine form and Russell Wilson is enjoying the best start to a season in his career. MVP is a word bandied around where he’s concerned.

His Cleveland counterpart, Baker Mayfield, is enjoying no such praise. Mayfield was sacked repeatedly, picked off and tormented senseless by Nick Bosa and the Niners defense. The Browns were awful in the loss on all fronts and that doesn’t bode well.

Pete Carroll will most likely take stock of how the Niners outclassed, outplayed and outmuscled the Browns and have his Seahawks replicate the very same result at the Dawg Pound. As such, don’t be surprised, if this game is nowhere nearly as close as the NFL odds would have it.

NFL Betting Trends

— Seahawks are 7-1-0 ATS in their last 8 games on the road
— Seahawks are 6-3 SU in their last 9 games on the road
— Browns are 2-5 ATS in their last 7 games at home
— The total has gone UNDER in 4 of Cleveland’s last 5 games vs Seattle

Key Injuries

SEA – G D.J. Fluker (Hamstring) is listed as day-to-day.

CLE – no new injuries noted.

Houston Texans vs. Kansas City Chiefs

Talk about role reversal. In a week when the Chiefs struggle and (shocker!) lose 19-13, the Texans light up behind a whopping 53-32 win over the Falcons. The upshot of this contrasting results is significant movement on the NFL odds board.

Vegas look ahead NFL lines has the Chiefs initially tipped as the -7.5 home faves. However, as money came down the wire the NFL line moved ever so conspicuously towards the Texans. Currently, the Chiefs are laying around -4.5 with most top-rated sportsbooks.

Obviously, this is a knee-jerk reaction to the results of Week 5 matchups. There’s also concern about Mahomes and his ankle injury, which was aggravated during the game and, in turn, likely contributed to the Chiefs losing for the first time this season.

How this game will go is up in the air, making it a bit of a tossup for Week 6 NFL picks. The Texans are quintessential grinders and could give the Chiefs a run for it, making them the potential value bet as the road underdogs to cover if not win outright. At the same time, Tyreek Hill could return for the Chiefs in this highly anticipated Week 6 clash. His return could very well make the difference for Mahomes and the Chiefs.

NFL Betting Trends

— The total has gone OVER in 9 of Kansas City’s last 13 games
— Chiefs are 3-6-0 ATS in their last 9 games at home
— Texans are 6-2 SU in their last 8 games on the road
— Texans are 1-4 SU in their last 6 games vs Chiefs

Key Injuries

HOU – C Greg Mancz (Concussion) is listed as day-to-day. CB Lonnie Johnson Jr. (Groin) is questionable for Sunday. C Zach Fulton (Back) and S Tashaun Gipson (Wrist) are both probable for Sunday.

KC – QB Patrick Mahomes (Ankle), LB Anthony Hitchins (Groin), DT Chris Jones (Groin), WR Sammy Watkins (Hamstring), DT Xavier Williams (Ankle), G Andrew Wylie (Ankle) all listed as day-to-day.

Washington Redskins vs. Miami Dolphins

While Vegas clearly tips this game in favor of the Washington Redskins, NFL bettors can’t overlook the fact that this is equally Miami Dolphins’ lone shot to avoid the dreaded 0-16 SU record in 2019. That is, if Miami actually tries to win a game this season. (There’s a lot of chatter about tanking in order to get at the front of the NFL draft queue.)

Let alone, the Redskins are going into week 6 with interim head coach Bill Callahan, who takes over after the Redskins fired Jay Gruden following Sunday’s loss to the New England Patriots. Callahan is already turning everything upside down, but can he effect a mental turnaround in less than a week. Another question, who will Callahan start at quarterback?

There are way too many unanswered questions ahead of this matchup that NFL bettors can’t possibly feel confident with either team in point spread betting markets. Perhaps, the best value bet in this game is going to be in total betting markets with a shade on the OVER. Neither team has a defense worth considering.

NFL Betting Trends

— Dolphins are 0-5-0 ATS in their last 5 games
— The total has gone UNDER in 4 of Miami’s last 6 games
— Redskins are 1-5-0 ATS in their last 6 games
— The total has gone UNDER in 5 of Washington’s last 6 games vs Miami

Key Injuries

WAS – DL Daron Payne (Knee) and T Donald Penn (Hamstring) are both listed as day-to-day.

MIA – WR Jakeem Grant (Hamstring), S Bobby McCain (Shoulder), both questionable for week 6 against Redskins.

Philadelphia Eagles vs. Minnesota Vikings

Is one win enough to reinstall faith that all is right in Minnesota’s camp? Just last week, Adam Thielen and Stefon Diggs took their grievances public, forcing Kirk Cousins to make issue apologies and so on. Yes, he made sure both had standout nights in the Big Apple last Sunday, but that was perhaps doable against a relatively lesser opponent in the Giants. Can he satisfy their demands against a much better team in the Eagles?

Put this way, will Zimmer let Cousins air it out against the Eagles more than he wants to? He might have to if Philly’s smoothing run defense has its way against the Vikings run offense. That could be a problem, however, because Carson Wentz is a much better quarterback that can put up the points in a hurry. Cousins is nowhere near that elite level and will be hard pressed to keep up.

All told, how the Vikings are the firm home favorites is a bit confusing. The method behind Vegas’ thinking aside, taking Philly and the points for Week 6 NFL picks has to be the smarter play as a result. Fun fact: Cousins is 5-27 all-time against teams with winning records.

NFL Betting Trends

— The total has gone UNDER in 6 of Minnesota’s last 7 games
— Vikings are 4-12-0 ATS in their last 16 games vs Eagles
— Eagles are 7-3 SU in their last 10 games
— The total has gone UNDER in 4 of Philadelphia’s last 5 games on the road

Key Injuries

PHI – RB Darren Sproles (Quadricep) is out indefinitely.

MIN – LB Ben Gedeon (Concussion) and CB Xavier Rhodes (Head) are both listed day-to-day.

New Orleans Saints vs. Jacksonville Jaguars

The Saints take a three-game winning streak into week 6 when they descend on the Jacksonville Jaguars, who are coming off their first loss in three games. This sets up a very interesting inter-conference battle between two backup quarterbacks – Teddy Bridgewater and Gardiner Minshew.

Vegas initially tipped this as a pick’em. Early betting has seen the Jaguars move up to -1 with most respected and trusted online sports betting outlets though. This move occurs despite both sides enjoy contrasting fortunes in week 5 and, importantly, Bridgewater having his best game yet with just over 300 passing yards and 4 TDs.

As much as Bridgewater is the feel-good story of 2019, the public fanfare over the Jags backup seems to be stronger. The public loves the Minshew Magic narrative. Nevertheless, if Bridgewater is proving to be more of a game manager and he hasn’t diminished the Saints’ chances for the playoffs as yet, taking the points with the Saints might be the value play here.

NFL Betting Trends

— Saints are 3-7-0 ATS in their last 10 games
— Saints are 8-3-0 ATS in their last 11 games on the road
— Jaguars are 5-10-2 ATS in their last 17 games
— Jaguars are 2-4-1 ATS in their last 7 games at home

Key Injuries 

NO – WR Deonte Harris (Lower Body) is listed day-to-day.

JAX – TE James O’Shaughnessy (Knee) is out for the season. DE Lerentee McCray (Oblique), and S Ronnie Harrison (Neck) are both listed as day-to-day. CB D.J. Hayden (Foot) and DE Josh Allen (Knee) are listed as questionable for Sunday. QB Gardiner Minshew II (Knee) listed as probable for Sunday.

Cincinnati Bengals vs. Baltimore Ravens

As opponents got tougher over the last three weeks the Baltimore Ravens have struggled, going just 1-2 SU in the last three games. Last Sunday, they only just edged a watered down Steelers side in overtime.

This less than stellar cross-section of games has had some NFL betting experts backpedal on any praise for Lamar Jackson and call attention to some glaring defensive issues with the Ravens.

So, at first glance, a double-digit spread for the Ravens on the NFL odds board is nerve-wracking. The Ravens haven’t reward spread bettors since week 1 of the 2019 season, going 1-4-0 ATS.

When said point spread involves the Cincinnati Bengals on the other side of the coin though, some of those concerns may be appeased. Put it this way, would you back the Bengals on Week 6 NFL picks at all?

Cincy isn’t great by any stretch of the imagination. They’re struggling on all sides of the ball and late game collapses have been their undoing in some games. Two weeks ago, they had their butts whooped by the Steelers in a 27-3 loss. This game could go in a similar vein.

NFL Betting Trends

— Ravens are 1-5-1 ATS in their last 7 games
— Ravens are 1-4-0 ATS in their last 5 games vs Bengals
— The total has gone OVER in 4 of Baltimore’s last five games
— Bengals are 0-5 SU in their last 5 road games

Key Injuries

CIN – WR Alex Erickson (Concussion) is out indefinitely. T Andre Smith (Ankle) and S Shawn Williams (Thigh) are listed as day-to-day.

BAL – TE Mark Andrews (Foot), LB Patrick Onwuasor (Ankle) and WR Marquise Brown (Ankle) listed as day-to-day. S Tony Jefferson (Knee) out for the season. CB Cyrus Jones (Foot), G Matt Skura (Knee) and DT Brandon Williams (Knee) are all listed as questionable for Sunday. TE Mark Andrews (Foot) listed as probable for Sunday.

San Francisco 49ers vs. Los Angeles Rams

Following San Francisco’s win in Monday Night Football over the Cleveland Browns, which underscored their credibility as one of two teams that remain undefeated in 2019, this game became suddenly even more interesting. Particularly, as the Rams are riding a two-game losing streak with losses to the Bucs and Seahawks in succession.

Early look-ahead NFL lines had the Rams favored considerably over the Niners but things are distinctly shifting against the Rams since week 5’s results. The Rams have seen their NFL odds come down from -4 to -3.5 and that trend could continue if more people buy what the Niners are selling.

Recent NFL betting trends are against the Niners, who have struggled against NFC West opponents. Niners are just 2-10 SU against their neighbours since 2017, but 5-7-0 ATS. That said, with the Rams struggling of late and Jared Goff and the offense looking off their game, the Niners could be primed to buck these recent trends. It’s still a big ask though and certainly taking the points with the Niners on Week 6 NFL picks isn’t a lock bet.

NFL Betting Trends

— LA Rams are 4-1-0 ATS in their last 5 games
— LA Rams are 3-5-2 ATS in their last 10 games at home
— Niners are 2-4-0 ATS in their last 6 games on the road
— Niners are 5-2-0 ATS in their last 7 games vs LA Rams

Key Injuries

LAR – LB Clay Matthews (Jaw) out until Mid-November. WR Brandin Cooks (Concussion) and LB Dante Fowler Jr. (hamstring) are listed as day-to-day.

SF – G D.J. Fluker (Hamstring) is listed as questionable.

Atlanta Falcons vs. Arizona Cardinals

Arizona Cardinals are coming off their first win of the season, but the NFL odds for week 6 are moving distinctly against them on the NFL odds board. Atlanta Falcons, meanwhile, lost 53-32 in Houston. A bit perplexing, don’t you think?

Vegas look-ahead NFL lines had the Falcons favored at -1. Now, they are trading almost as field-goal favorites over Arizona. There’s not a lot to like about either team, never mind feeling confident about their value in point spread betting markets. Falcons in particular as they are 3-7-0 ATS as road faves since 2017

If there is one bet to consider in this game for Week 6 NFL picks, it’s the total. Neither defense is up to snuff so it’s likely there could be plenty erratic scoring here.

NFL Betting Trends

— Cardinals are 4-2-0 ATS in their last 6 games
— The total has gone OVER in 4 of Arizona’s last 6 games
— Falcons are 1-5-0 ATS in their last 6 games
— The total has gone OVER in 4 of Atlanta’s last 6 games on the road

Key Injuries

ATL – S Damontae Kazee (Concussion) is listed as day-to-day. P Matt Bosher (Groin) is out indefinitely.

ARI – RB David Johnson (Back) and CB Tramaine Brock Sr. (Shoulder) are both listed as day-to-day.

Tennessee Titans vs. Denver Broncos

The Titans have been underwhelming through the first few weeks of the 2019 season. Most recently, the Titans are flush off a 14-7 loss at home to the Bills, failing to come through for their backers as the home favorites (-3 closing).

The Titans are 2-3-0 ATS this season with both covers coming on the road. In Week 1, they beat the Browns 43-13 and in week 4 they upset the Falcons 24-10 on the road. Will this road trend continue for the Titans when they take on the Denver Broncos, who are coming off their first win of the season?

At face value, the 1-4 SU Broncos look beatable. So, one can’t write off the Titans out of hand just like that. Then again, there is an argument to be had about the Broncos being better than their record would suggest. That they’re unfortunate to be sporting just one win on the season.

If Denver can make it two wins in a row though, the Broncos could be the sneaky turnaround team you won’t want to miss for your Week 6 NFL picks.

NFL Betting Trends

— Broncos are 2-7-0 ATS in their last 9 games
— Broncos are 1-7 SU in their last 8 games at home
— Titans are 2-5-0 ATS in their last 7 games
— The total has gone UNDER in 4 of Tennessee’s last 5 games

Key Injuries

TEN – LB Sharif Finch (Shoulder) and CB Chris Milton (Calf) are listed as day-to-day. LB Daren Bates (Ankle), S Kenny Vaccaro (Groin) and TE Delanie Walker (Knee) are all listed as probable for Sunday. RB David Fluellen (Knee) is out indefinitely.

DEN – CB De’Vante Bausby (Neck) is out indefinitely. LB Justin Hollins (Knee) is listed as day-to-day.

Dallas Cowboys vs. New York Jets

Sam Darnold has been cleared to start for the New York Jets in week 6, but will his return make much of a difference to the beleaguered 0-5 SU Jets? It’s hard to say, when we’ve only seen one game from the starter and it was nothing to write home about as the Jets fritted away a big lead to the Bills in week 1.

Dallas Cowboys have struggled in recent weeks and are on the heels of back-to-back losses to the Saints and Packers. By and large, though, this is being dubbed a gimmick game for the Cowboys. A perfect launchpad to bounce back into the win column.

In the first three weeks, Dak Prescott and the Cowboys roughed up lesser opposition and handsomely rewarded their backers. They came through in 35-17 win over the Giants as the -7 closing favorites; in a 31-21 win over the Redskins as the -6 closing favorites; and the staggering -22 closing favorites in a 31-6 win over the Dolphins. Colour the world shocked if the Cowboys don’t come through for NFL bettors in this clash.

NFL Betting Trends

— Jets are 1-5-1 ATS in their last 7 games
— The total has gone UNDER in 4 of NY Jets’ last 5 games
— Cowboys are 4-1-1 ATS in their last 6 games vs Jets
— The total has gone UNDER in 6 of Dallas’ last 8 games

Key Injuries

DAL – T La’el Collins (Knee) and WR Amari Cooper (Foot) are both listed day-to-day.

NYJ – QB Sam Darnold (Spleen), DL Henry Anderson (Shoulder), QB David Fales (Head) and G Kelechi Osemele (Knee) are listed as day-to-day. LB Tarell Basham (Conditioning), WR Josh Bellamy (Shoulder), TE Daniel Brown (Ankle) and RB Trenton Cannon (Hamstring) are listed as questionable for Sunday.

Pittsburgh Steelers vs. Los Angeles Chargers

Although Mike Tomlin is yet to confirm his starter for Week 6, the NFL betting market is decisively stood against the Steelers. Clearly, Vegas doesn’t feel starting Mason Rudolph or third-string backup Devlin Hodges will make much of an impact to the bottom line.

This may have a lot to do with preseason perceptions, in which the Los Angeles Chargers dubbed Super Bowl contenders. Certainly, it’s not down to the Chargers current form, which is a woeful 2-3-0 SU going into week 6 and has head coach Anthony Lynn visibly offended. Especially, by their listless performance in a week 5 loss to divisional rivals, Denver Broncos.

How can NFL bettors take the Chargers seriously as the massive home favorites in this game? They’re not playing up to their potential and they’re dealing with their fair share of injuries as well. Put it this way, they’ve been a nightmare for backers in point spread betting markets with a 1-4-0 ATS record. Their only cover was against the Dolphins, and even that took effort it seemed.

NFL Betting Trends

— Chargers are 1-4-1 ATS in their last 6 games
— Chargers are 0-4-1 ATS in their last 5 games at home
— Steelers are 2-3-1 ATS in their last 6 games
— Steelers are 2-3-1 ATS in their last 6 games on the road

Key Injuries

PIT – QB Mason Randolph (Concussion) is out indefinitely. LB Mark Barron (Hamstring) and WR James Washington (Shoulder) are both listed as day-to-day. WR JuJu Smith-Schuster (Toe), RB James Conner (Ankle), DT Cameron Heyward (Quadricep) are all listed as probable for Sunday.

LAC – LB Denzel Perryman (Ankle), C Mike Pouncey (Neck) and S Nasir Adderley (Hamstring) are all listed day-to-day.

Detroit Lions vs. Green Bay Packers

The highly anticipated NFC North showdown is sure to be a right cracker for Monday Night Football betting enthusiasts. Both teams are riding high in 2019 and winning the premium on the win in this clash can’t be understated.

The Packers have already faced two divisional opponents – Vikings and Bears – and come away victorious. They’ll be eager to make it a trifecta in the early goings, particularly as the Lions have had their number in recent years. For the Lions, this is their first divisional game of the season so the weight of expectation is going to be great.

The Lions have the advantage of rest ahead of this clash, coming off a bye in week 5. Most recently, they gave the Kansas City Chiefs a run for their money in a narrow loss at Ford Field.

The Packers are coming off a statement win over the Dallas Cowboys at AT&T Stadium, in which Rodgers and Jones lit up the scoreboard.

Given everything we’ve seen from both these teams, this game could very well be closer than the NFL odds would suggest. As such, taking the points with the Lions may be the smart bet to cover.

NFL Betting Trends 

— Packers are 4-1-0 ATS in their last 5 games
— Packers are 1-4-0 ATS in their last 5 games vs Lions
— Lions are 4-1-0 ATS in their last 5 games
— Lions are 4-1 SU in their last 5 games vs Packers

Key Injuries

DET – DB Quandre Diggs (Hamstring), TE T.J. Hockenson (Concussion), WR Danny Amendola (Chest), CB Darius Slay (Hamstring) are all listed as questionable for Monday Night Football (MNF)

GB – K Mason Crosby (Leg), CB Kevin King (Knee), C Corey Linsley (Concussion), S Darnell Savage (Ankle), LB Preston Smith (Knee), Za’Darius Smith (Knee), TE Robert Tonyan (Hip), and LB B. J. Goodson (Neck) are all listed day-to-day.

Bye Week: Buffalo Bills, Chicago Bears, Indianapolis Colts, Oakland Raiders

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